Can A Low Thyroid Be Causing Your Dry Skin? By: Teri Dourmashkin | - Hypothyroidism or low thyroid, can cause a myriad of symptoms and can even lead to more serious disease if left untreated. Oprah Winfrey made national headlines when she recently announced on her syndicated TV talk show that she had a low thyroid. This undoubtedly brought increased awareness to this condition.