Rational high throughput screening assays allows the discovery of new inhibitors against specific targets. It allows the design of specific inhibitors like hdac inhibitors, egfr inhibitors, kinase inhibitors etc. Research has shown that more than 30% of the marketed drugs target a broad category of receptors named as G protein coupled receptors (GPCRs). The reason behind this extensive targeting of GPCRs is their important role in a variety of ailments especially cance ... Tags:INHIBITOR
A steady blood flow is the only case of prevention of atherosclerosis. A shear stress can cause the prevention of hardening of blood vessels. So when a shear stress is exerted by flow of fluid, it results in the in vivo prevention of atherosclerosis. Atherosclerosis leading to oxidative stress also accompanied with expression of VCAM1 increased inflammation.. A steady blood flow decreases VCAM1 expression mediated by TNF-?. BIX02188 is among MAPK inhibitors and selectiv ... Tags:AZD6244, Selumetinib, xl880
Vision Shopsters: The Future Of Gpcrs In Drug Discovery: Novel Technologies, Leading Companies By: Visionshopsters | - G-protein coupled receptors (GPCRs) constitute the largest, most ubiquitous, and most versatile family of membrane receptors. They also constitute the class of targets that has been most effectively exploited by the pharmaceutical industry, with approximately 30% of all currently marketed drugs acting on one or more GPCRs. Despite this, there are many GPCRs that have yet to be effectively exploited, for a variety of reasons. A number of new approaches to GPCRs are being explored that should lead ... Tags:Future, GPCRs, Drug Discovery, Novel, technologies, leading
The PHERAstar FS is the ultimate multidetection microplate reader for HTS and assay development, especially where speed and sensitivity are imperative.
The compact and versatile PHERAstar FS microplate reader is able to perform all leading non-isotopic detection technologies.
Gpcrs: Exploring New Paradigms By: Stephen | - As one of the largest and most diverse protein families in nature, the G-protein coupled receptor (GPCR) superfamily play important roles in a variety of biological and pathological processes such as development and proliferation, neuromodulation, angiogenesis, metabolic disorders, inflammation, and viral infection. Not surprisingly, it is one of the most targeted protein families in pharmaceutical research today (Schlyer 2006).
All members of this superfamily share a similar ... Tags:GPCRs, protein, receptor
