How Metformin Works

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Metformin is a dimethyl biguanide group is Oho used to lower blood glucose levels in patients with type 2 diabetes, its use aims to reduce insulin resistance by improving insulin sensitivity of tissues. Thus, metformin is indicated as first choice drug in obese patients with type 2 diabetes in which the basic disorder is insulin resistance. Although metformin is a different way of working with SU but the effect of glycemic control similar to the class of sulfonyl urea (SU). Sulfonyl urea can cause weight gain metformin is not the case. Moreover SU hypoglycemic effect often found with metformin is rare. Therefore, metformin is known to work as an anti-hyperglycemia being the SU as a drug that works as a hypoglycemic.

Metformin may be indicated as initial therapy or adjunctive therapy in patients who received the SU which does not give satisfactory results. Unlike SU, metformin is not bound to plasma proteins, not metabolized and excreted rapidly by the kidneys.

Mechanism action of metformin increase up-take (utilization) diperifer glucose by increasing tissue sensitivity to insulin, suppresses the production of glucose by the liver, lowering Fatty acid oxidation and increase the use of glucose in the intestine through a non-oxidative process. Extras lactate formed would be extracted by the liver and used as raw materials gluconeogenesis. This situation prevents the effect of excessive glucose levels decrease.

500-850 mg dose of metformin administered with food in the morning and evening. The dose can be increased by adding 1 tablet every 1-2 weeks delivery intervals. Total dose can reach 3-4 times the 500 mg or 850 mg 2-3 times per day if needed. Maximum dose of 3000 mg per day.

Metformin side effects are gastro intestinal disorders such as diarrhea, anorexia or feeling sick to your stomach. Lactic acidosis is rare (0.03 per 1000 patients per year). Usually occur when administered to patients who contraindications.

Metformin can not be given to renal function impairment, heart disease, cor pulmonale, a history of lactic acidosis, severe infections, impaired liver physiology, alcohol poisoning, and the use of intravenous radiographic contrast material. Just pay more attention for that.

Above is some explain how ,metformin works. If you are enjoyed and interested to know more about it, please visit the link at the resource box below.


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