Fluconazoles, Fungal Infections

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Fluconazoles can effectively treat fungal infections. It is a triazole antifungal drug used in the treatment and prevention of candidiasis and cryptococcal meningitis. Meningitis is the infection of the membranes covering the brain and spine. Moreover, it is also used to treat yeast infections of the vagina, mouth, throat, esophagus, abdomen, lungs, blood and other organs.

Fluconazoles are also used to prevent yeast infections in patients who are likely to become infected because they are being treated with chemotherapy or radiation therapy before a bone marrow transplant. It works by inhibiting the fungal cytochrome P450 enzyme 14-demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and subsequent accumulation of 14-methyl sterols.

Fluconazole indicated for the treatment and prophylaxis of fungal infections where other antifungals have failed or are not tolerated. It is active against the microorganisms like Blastomyces dermatitidis, candida spp. (except C. krusei and C. glabrata), Coccidioides immitis, Cryptococcus neoformans, Epidermophyton spp., Histoplasma capsulatum, Microsporum spp., and Trichophyton spp. This medicine is used as a first-line drug for coccidioidomycosis, cryptococcosis, histoplasmosis, and prophylaxis of candidiasis in immunocompromised people. Fluconazoles are primarily fungistatics. It may be fungicidal against certain organisms in a dose-dependent manner.

Dosages of fluconazoles vary, depending on the indication. The usual dosage for vulvovaginal candidiasis is 150 mg per day for two-week. Dosage for resistant skin infections or some prophylactic indications is 150 mg to 300 mg once weekly. For systemic or severe infections it is 500 mg to 600 mg per day may be used. In urgent infections such as meningitis caused by yeast, 800 mg per day have been used. Pediatric doses are measured at 6 mg to 12 mg/kg/d. A loading dose will be indicated when entering a daily dosage schedule. For example, a loading dose of 200 mg on the first day is commonly used with 150 mg per day following it.

When taken orally fluconazole is almost completely absorbed within two hours. Medicines can interact with other medicines you are already taking. They may also be contraindicated in some cases. For this reason it is always advised to take medicines under doctors supervision.

About the Author:
Bhupinder Kaur Khera is an online writer. She has studied on how to achieve a healthier, balanced lifestyle and have access to the essential medicines they need. For free expert advice on safe, effective and assured quality fluconazoles medicines visit http://www.rx2gostore.com/Fluconazole.php



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