Diabetic Glycation And Pre-diabetes

The bonding of a sugar like glucose to a protein or a fat is called Glycation, and it's not a good thing. At times the protein does need a sugar molecule in its structure to function properly. It does this enzymatically - there is another name for this action.

Glycation, on the other hand, is a haphazard mating the protein doesn't seek. Why? Because this type of marriage ends up negatively altering the protein so significantly it undermines the functional efficiency of the protein.

Table sugar is sucrose, it's made up of glucose and fructose. They are divided in the stomach and then absorbed into the blood. Fructose is ten times more able to glycate than glucose.

Sugars are sticky molecules, and the more there are, and the longer they hang around the greater the chances for glycation.

Glycations interfere with molecular and cellular functioning throughout the body as well as to throw off highly-oxidizing, toxic, side-products such as hydrogen peroxide.

Long lived cells in the brain and nerves, long lasting proteins, and DNA suffer severe damage over time as a result of glycation. Even the beta cells in the pancreas, the insulin producing cells that could have reversed glycation are attacked. Glycation weakens as well as stiffens blood vessels, perhaps The worst of its actions.

AGEs, advanced glycation end products are what the glycated molecule ends up being, basically it is a toxic waste product. Essentially there are no tissues that are immune to glycation therefore all organs and system are vulnerable to chronic diseases: Alzheimer's, cardiovascular, cancer, neuropathology's, diabetes, eyes, ears, etc, etc.

Red blood cells are easily accessible and therefor can be easily measured for increases in glycating material. Recently it has been determined that the monitoring of the state of diabetes is best done by determining HbA1c. HbA1c is the measurement of glycated hemoglobin levels in the cells.

Other pathologies are active in diabetes beyond glycation, but more is known about this process so it gets the most attention.

As you can see, diabetes is definitely a life shortening disease to be feared. Early diabetes and especially during pre-diabetes one still has time to actively back out of the mess ahead.

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Tags: Effects of high blood sugar

, what causes diabetes

, causes of high blood sugar

, insulin resistance

, blood sugar tests

, prediabetes

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